Angiotensin converting enzyme ii, angiotensin converting enzyme ace inhibitor, angiotensin converting enzyme ace, human angiotensin converting enzyme 2, angiotensin converting enzyme 2, angiotensin converting enzyme inhibitor drugs, angiotensin converting enzyme inhibitors, what is angiotensin converting enzyme 2, angiotensin converting enzyme test, human angiotensin converting enzyme 2, angiotensin converting, angiotensin converting enzyme 2 in the kidney, angiotensin converting enzyme ace 2, angiotensin converting enzyme high, angiotensin converting enzyme 2, ace converts angiotensin 1 to angiotensin 2.
Angiotensin-Converting Enzyme-2 (ACE-2) with Interferon-Induced Transmembrane Protein-3 (IFITM-3) Genetic Variants and Interleukin-6 as Severity and Risk Predictors among COVID-19 Egyptian Population.
Abstract
The host genetic background is a crucial factor that underlies the interindividual variability of COVID-19 fatality and outcomes. Angiotensin-converting enzyme-2 (ACE-2) and interferon-induced transmembrane protein-3 (IFITM-3) have a key role in viral cell entrance and priming. The evoked immune response will also provide a predictive prognosis for COVID-19 infection. This study aimed to explore the association between ACE-2 and IFITM-3 genotypes and their corresponding allele frequencies with disease severity indices in the Egyptian COVID-19 population. The serum level of interleukin-6, as a biomarker of hyperinflammatory response, and cytokine storm, was correlated with disease progression, single nucleotide polymorphisms (SNPs) of the selected receptors, and treatment response. Methodology. We enrolled 900 COVID-19-confirmed cases and 100 healthy controls. Genomic DNA was extracted from 200 subjects (160 patients selected based on clinical and laboratory data and 40 healthy c ontrols). The ACE-2 rs2285666 and IFITM-3 rs12252 SNPs were genotyped using the TaqMan probe allelic discrimination assay, and the serum IL-6 level was determined by ELISA. Logistic regression analysis was applied to analyze the association between ACE-2 and IFITM-3 genetic variants, IL-6 profile, and COVID-19 severity. The identified genotypes and their alleles were significantly correlated with COVID-19 clinical deterioration as follows: ACE2 rs2285666 CT + TT, odds ratio (95% confidence interval): 12.136 (2.784-52.896) and IFITM-3 rs12252 AG + GG: 17.276 (3.673-81.249), both p < 0.001. Compared to the controls, the heterozygous and mutant genotypes for both SNPs were considerable risk factors for increased susceptibility to COVID-19. IL-6 levels were significantly correlated with disease progression (p < 0.001). ACE-2 and IFITM-3 genetic variants are potential predictors of COVID-19 severity, critical outcomes, and post-COVID-19 complications. Together, these SNPs and ser um IL-6 levels explain a large proportion of the variability in the severity of COVID-19 infection and its consequences among Egyptian subjects.
Authors (8) : Amal F Makled, Sahar A M Ali, S S Eldahdouh, Asmaa S Sleem, Maha M Eldahshan, Yara Elsaadawy, Samar S Salman, Asmaa Mohammed Elbrolosy
Source : International journal of microbiology
Article Information
| Year | 2023 |
| Type | Journal Article |
| DOI | 10.1155/2023/6384208 |
| ISSN | 1687-918X |
| Volume | 2023 |
You can download journal here :
If You have any problem, contact us here
